RESEARCH FELLOWS

St. Bartholomews and the Royal London

2006-2009 Dr Jenny Epstein Acetylation: A critical factor in maintaining intestinal inflammation.

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St. Bartholomew’s Hospital London

2000-2003 Dr Andrew Sawzcenko Epidemiology of growth failure in childhood Crohn's disease.

2000 -2001 Dr Kay Dryhurst Growth failure in childhood Crohn’s Disease.

1993 -1995 Dr Mark Beattie The role of enteral nutrition in the treatment of Crohn’s disease in childhood.

1990 - 1993 Dr Stuart Nicholls Cyclosporin in childhood Crohn’s disease.

1987 -1990 Dr Mark Evans Tissue damage and repair in human colon.

1985 - 1986 Dr Lisa Lipson Growth disturbance in children with Crohn’s disease.

1983 - 1985 Dr Ian Sanderson The role of an elemental diet in the management of children with Crohn’s disease.

1981 - 1983 Dr Sonny Chong Clinical and pathological studies in childhood Crohn’s Disease and Immunomodulatory effects of the properties of panax ginseng.

1979 - 1980 Dr John Douglas Define more accurately the precise diagnostic criteria for Crohn’s Disease in children. 

St. Bartholomew’s/Royal Free

2004-2006 Dr Satish Keshav/Dr Sanjay Lala - Royal Free Hampstead - Nod2 in Panth Cells

1997 –1999 Dr Robert Heuschkel Enteral Nutrition in inflammatory bowel disease in childhood.

1995 - 1997 Dr John Fell Mucosal healing and reduction in inflammation in response to a polymeric diet in paediatric Crohn’s.

Booth Hall Children’s Hospital, Manchester

1996 -1998 Dr A Akobeng MD The role of glutamine in paediatric Crohn’s disease.

1994 -1996 Dr Elbadri Study in glutamine supplemented elemental diet.

1991 -1993 Dr Egware Odeka Use of an enriched fat (hiolien) in fat utilization studies in patients with Crohn’s disease.

1989 - 1990 Dr F A Sagher Carbohydrate absorption and oxidation in children with Crohn’s disease.

1988 - 1989 Adrian Thomas MD Use of stable isotopes to studamino-acid in uptake in Crohn’s disease.

University of Southampton

2001 - 2004 Dr Ronald Bremner The role of Smad7 in inflammatory bowel disease  - Click here to read his final report!

PhD STUDENTSHIPS

2009   Nicola Gellatly
Mucosal dendritic cell function.

2006   Ida Riciardelli 
Exploration of how current theraputic strategies target pro-inflammatory pathways can influence the destiny and function of regulatory lymphocytes.

2002   Lindsey Edwards
Intestinal Responses to Bacterial Components  as risk factors for Crohn’s Disease

2001   Cassie Davies
Quality of Life study

2000   Marcus Bachler
The role of the OX40 as a new treatment for Crohn’s disease.

1997   Natalie Goncalves
Development, mechanisms and therapies of the immune gut injury in the IL-2 KO model

1996   Lisa Higgins
Co-stimulatory molecules involved in the pathogenesis of inflammatory bowel disease

1994   Stuart MacDonald
Investigating the mechanisms of intestinal injury in  genetically-modified mice lacking the Interleukin-2

1992   Sylvia Pender (nee Cheng)
Extra cellular matrix protein degradation  during intestinal damage

1991   Anna Bellhouse
Gamma-delta T cells

1991   Jacqueline Taylor
Activated T-cells and their effects on gut inflammation

1988   Louise Forsyth
Mechanism of T-cell mediated damage in human small intestine

1988   Teresa Monk
Mechanisms of T-cell mediated damage in human small intestine

1988   Jo Viney
The phenotype and function of intraepithelial   lymphocytes

RESEARCH PROJECTS

2007-2009 Dr Andrew Barclay - University of Glasgow - Measuring the Activity and Diversity of the Gut Microbial Flora using Stable Isotope Probing.

2000-2003 The National Register of Paediatric Inflammatory Bowel Disease based at Alder Hey Children’s Hospital, Liverpool.

2000 -2002 Dr Lindley, Institute of Child Health, London – Activation of epithelial and endothelial Toll-Like receptors in idiolpathic inflammatory bowel disease.

2000 - 2001 Dr M J Carter, University of Sheffield – Genetics of Ulcerative Colitis.

2000 Dr J Spencer – Repertoire and origin of mucosal IgG in ulcerative colitis.

1999 - 2001 Professor G W Stamp, Hammersmith Hospital - The role of trefoil peptides in Crohn’s disease.

1999 Dr Anne Ballinger, Barts – Inhibition of insulin-like growth factor (IGF-1) mediates growth failure in i.b.d.: single or multiple cytokine effect?

1997 Dr H Jenkins, University Hospital, Cardiff – An in vitro study of the effects of cytokines on osteoblast differentiation and function.

1997 Dr F Fortune – Guys & St. Thomas’s Hospital – In vivo diagnosis and in vitro analysis of Crohn’s disease in children.

1996 Dr J Spencer, Guys and St. Thomas’ Hospital – A study of the contribution of natural antibodies and affinity matured antibodies to the humoral immune system in childhood i.b.d.

1995 -1996 Dr C Probert, University of Bristol – Identification and isolation of pathogenic T-cell clones in Crohn’s disease.

1995 Dr J Gibson – University of Glasgow Dental School – A clinical and molecular biological study in aetiology of oral Crohn’s disease and its relationship to gut Crohn’s disease in childhood.

1995-1997 Dr Pignatelli, Hammersmith Hospital – Regulation of E-cadherin/catenin expression and functions in Crohn;s disease; a possible mechanism in mucosal regeneration.

1995-1996 Dr D R Mathew – Guys Hospital – Genetic linkage studies in Crohn’s and ulcerative colitis.

1995 Dr Vivien Rolfe – GOS – The effects of Metronidazole on neutrophil trafficking and pathogenesis of Crohn’s disease in human intestinal biopsies in vitro.

1995 Dr J Mayberry – A young people’s clinic for patients with I.b.d.

1993 Dr J Mayberry, Leicester – Valid quality of life measure in young people.

1992 -1993 Dr R Allen , Birmingham The role of antigen-specific induced secretion of cytokines in the immunopathology of i.b.d.

1992 -1993 Dr G W Stamp - Molecular mechanisms of natural intestinal ulcer healing in Crohn’s disease.

1992-1994 Prof. Anne Ferguson - Juvenile-onset inflammatory bowel disease: audit of delivery and efficacy of hospital-based health care.

1991 -1992 Dr J Spencer - Molecular studies of the T cell receptor.

1991-1993 Professor J Lennard-Jones – Genetic aspects of Crohn’s disease.

1990 -1991 Dr P J Milla - Body composition during treatment for Crohn’s disease.

1989 -1991 Prof. J Rhodes - Anti- tuberculosis chemotherapy trial in Crohn’s disease.

1989 -1990 Dr P Quirke, Leeds - Has mycobacterium paratuberculosis a role in Crohn’s disease?

1989 -1990 Dr R Pounder, Royal Free Hospital, London - Is Crohn’s disease caused by a chronic persistent viral infection? Vascular injury in Crohn’s disease.

1989 Dr P Pease – Birmingham - The nature and distribution of antigens common to bacteria and the lymphocytes from patients with i.b.d.

1989 -1990 Dr J Mayberry, Nottingham - An epidemiological study of i.b.d. amongst Jewish people in Great Britain and Ireland and the identification of aetiological factors.

1989 Dr C Ainley – St. Thomas’ Hospital, London - A dietary cause of Crohn’s Disease.

1989 Dr C Ainley – St. Thomas’ Hospital, London - A dietary cause of Crohn’s Disease.

1988 -1997 Professor A Ferguson - Epidemiology, clinical assessment, morbidity and mortality of Scottish children with inflammatory bowel disease.

1988 -1989 Dr G Bottazzo - Middlesex Hospital - The regulation of aberrant Class 11 molecule expression ion Crohn’s disease and its possible role in the pathogenesis of this condition.

1988 -1989 Professor R Wright – Southampton Hospital – Gene probing in Crohn’s disease.

1987 -1989 Dr R Allen – The nature and distribution of antigens common to bacteria and the lymphocytes from patients with i.b.d.

1987 -1989 Dr R Allen – The nature and distribution of antigens common to bacteria and the lymphocytes from patients with i.b.d.

1987 Prof. J Polek - Hammersmith - Peptides.

1986 -1987 Dr Dourmashkin – Middlesex Hospital – Mycrobacterial studies.

1985 -1987 Prof. A Ferguson – Western General Hospital – Study of Chronic Inflammatory Bowel disease in Scottish children (Prevalence, clinical features, nutritional effects).

1984 Part salary for Auxologist – St. Bartholomew’s Hospital.

1983 onwards Salaries, Equipment and day to day running costs, Paediatric Gastroenterology Laboratory, St. Bartholomews Hospital.

1981 -1983 Queen Elizabeth Hospital for Children, Hackney – David Lewis Research Assistant to Dr Alan Phillips, Electron Microscopist.